(TTTA)n polymorphism of CYP19 (aromatase gene) in Euro- and Afro-Brazilians
نویسندگان
چکیده
منابع مشابه
(TTTA)npolymorphism of CYP19 (aromatase gene) in Euro- and Afro-Brazilians
We investigated the polymorphic tetranucleotide repeat (TTTA)n located in the fourth intron of the CYP19 gene in two Brazilian populations. The frequencies of the five common alleles (A) in Euroand Afro-Brazilians were, respectively: seven repeats (A5), 0.586 and 0.80; eight repeats (A4), 0.092 and 0.06; nine repeats (A3), 0.014 and 0.01; eleven repeats (A2), 0.284 and 0.09; twelve repeats (A1)...
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15 صفحه اولThe (TTTA)n polymorphism of aromatase (CYP19) gene is associated with age at menarche.
BACKGROUND Twin studies have shown that age at menarche may be subject to hereditary influences but the specific determinants are unknown. Estrogens are known to have an important role in menarche. Since the enzyme aromatase is responsible for the conversion of androgens to estrogens, the aromatase (CYP19) gene could be a candidate gene for the regulation of menarche. The aim of this study was ...
متن کاملAssociation between gynecomastia and aromatase (CYP19) polymorphisms.
OBJECTIVE Aromatase cytochrome P45019 (CYP19) is a key enzyme in estrogen biosynthesis, and polymorphisms within its gene are associated with an increased risk of estrogen-dependent diseases. Enhanced estrogen stimulation of breast tissue in men may lead to gynecomastia. We assessed whether intron 4 (TTTA)n repeat and TCT deletion/insertion polymorphisms and an exon 10 (3'-UTR) C/T single nucle...
متن کاملSimple tandem repeat (TTTA)n polymorphism in CYP19 (aromatase) gene and breast cancer risk in Nigerian women
BACKGROUND Breast cancer is the most common cancer and the leading cause of cancer related deaths in women worldwide. The incidence of the disease is increasing globally and this increase is occurring at a faster rate in population groups that hirtherto enjoyed low incidence. This study was designed to evaluate the role of a simple tandem repeat polymorphism (STRP) in the aromatase (CYP19) gene...
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ژورنال
عنوان ژورنال: Genetics and Molecular Biology
سال: 2004
ISSN: 1415-4757
DOI: 10.1590/s1415-47572004000300005